Study Reviews on Hyaluronic Acid (HA)
Will the Real Hyaluronan please stand up?
There are many Hyaluronic Acid products available now on the market. This review from the Journal of Applied Nutrition examines the different kinds of HA available and talks about their effectiveness. Not all Hyaluronic Acid is created equal. Keep in mind when reading this study that our patented Synthovial Seven® is high molecular weight HA in the 2.4-3 million Daltons!
Excerpt from the review summary-
"..dietary supplements containing HA are not equivalent due to the inherent properties of the three major types of HA commercially available as dietary supplement materials. Consumers and health care professionals need to be aware of the different types of HA and their very large differences in properties (even before ingestion). One source, hydrolyzed chicken sternal cartilage, is clearly unlike native HA, does not match the biological properties of native HA, and consequently should not be represented as HA to consumers on product labels..."
Click here to read this entire review (pdf)
Proven bioavability and absorption with High Molecular Weight HA
Oral Absorption Study
Washington. D.C., April 18, 2004 – A consortium of scientists released clinical research results about oral delivery of radiolabeled Hyaluronan (HA) and its ability to be taken up by joints. Dr. Alex Schauss, Director of AIBMR, presented the findings at the 2004 Experimental Biology conference, conducted by the Federation of American Societies for Experimental Biology.
Hyaluronan has been used for years in veterinary and human medicine as an injection to replace lost joint fluid. The study was led by Dr. Schauss and conducted by a consortium of scientists from the Life Sciences Division of the American Institute for Biosocial and Medical Research Inc. in Puyallup, Washington and the National “FJC” Research Institute for Radiobiology and Radiohygiene, National Institute for Health in Budapest, Hungary. The research was supported by Weider Nutrition International.
“This is the first time hyaluronic acid has been reported to be absorbed orally, which paves the way for HA dietary supplements to be introduced and deliver on anti-aging and joint health promises,” said Dr. Luke Bucci, Ph.D., Vice President of Research for Weider Nutrition International.
Until now, there was no data on pharmacokinetics after oral intake and the therapeutic use of hyaluronic acid was limited to injections or topical applications. The results of this study, which examined the absorption, excretion and distribution of radiolabeled HA after a single oral administration in Wistar rats and Beagle dogs, demonstrated that HA is absorbed and distributed to organs and joints after a single oral administration.
Excerpt from Abstract # 129.4- Absorption, distribution and excretion of 99mtechnetium labeled hyaluronan after single oral doses in rats and beagle dogs
This study examined the absorption, excretion and distribution of radiolabeled hyaluronan (HA) after a single oral administration in Wistar rats and Beagle dogs. High Molecular Weight HA from bacterial fermentation was radioactively labeled with 99-technetium and its oral uptake in rats and dogs was studied. Uptake of HA into the bloodstream (5% of an oral dose) was found, and scintigraphy found uptake of labeled HA into joints (FASEB, 2004). A. G. Schauss, L. G. Balogh, A. G. Polyak, D. G. Mathe, R. G. Kiraly and G. G. Janoki American Institute for Biosocial and Medical Research, Inc and National Institute for Health.
Thus, purified, high molecular weight HA is bioavailable and delivered to joints. From these results,
approximately 4.5 billion molecules of HA may reach each knee joint after oral
ingestion of 3 mg of HA in humans. These results demonstrate that HA is absorbed and distributed to organs and joints after a single oral administration.
An abstract with complete research details was published in the April issue of FASEB Journal.
